Major Depressive Disorder

Depressed mood most of day, anhedonia, weight changes, sleep disturbances, fatigue, worthlessness/guilt, poor concentration, thoughts of death

Genetic, neurochemical (serotonin, norepinephrine), psychological factors, life events, medical conditions, medications

Antidepressants (SSRIs, SNRIs, etc.), psychotherapy (CBT, interpersonal therapy), ECT for severe cases, lifestyle modifications, social support

Assess suicide risk, promote medication adherence, provide emotional support, teach coping strategies, monitor for side effects

Source: NHS Scotland. For educational purposes only.